Endocrine Abstracts

Impaired glucagon suppression is an overlooked contributor to the transition of prediabetes to type 2 diabetes. We used Graded Glucose Infusion (GGI) to examine the relationship of ISR and Glucagon Secretion Rate (GSR) with rising glucose. We studied 39 non-diabetic, weight-stable individuals (53±2 yrs, 30±1 Kg/M2) categorized by fasting and glucose tolerance status following a 75g OGTT at the time of screening. After an overnight fast, at 07:00 a variable ins...

Late night salivary cortisol measurements have been increasingly used as an initial diagnostic test for the evaluation of patients with a clinical suspicion of Cushing syndrome (CS). Published studies include varying numbers of cases and controls and importantly various assay methods (usually immunoassays), as well as various methods of generating normative values.Materials and methods: We examined the diagnostic utility of salivary cortisol measurement ...